The Nano-oncology laboratory focuses in the generation of new tools for the diagnosis, evaluation and monitoring of cancer through the application of nanotechnology, with the aim of offering new products with application in oncology.
Therefore part of our research is centred in the formulation of nanoparticles based on biocompatible and biodegradable compounds with the capacity to interfere in the cell biology. On the other hand, our laboratory possess the capacity to modify these nanosystems through their functionalization, by the application of different chemical approaches. The modification of the nanosystems can be done with different ligands (antibodies, aptamers or peptides), with the aim of targeting, therefore generating new tools for the isolation and culture of Circulating Tumor Cells (CTCs). Moreover, due to the biocompatibility of the formulated functionalized nanoparticles they can be applied for therapy.
Furthermore, we are developing diagnostic tools for the detection of biomarkers which are involved in cancer metastasis, by exploiting the optical properties of inorganic nanoparticles. Therefore, we synthesize metallic nanoparticles, principally gold nanoparticles, following by their functionalization with different ligands. The modification of physico-chemical properties of these nanoparticles and consequently their of their optical properties modification, offer the new tools in the detection of circulating tumor material.
Dr. Ana Belén Dávila Ibañez, is the responsible of the Nano-oncology laboratory of the Roche-Chus Joint Unit