ROBERTO

Roberto Piñeiro Cid

Head of the Cancer Modelling Line of the Roche-Chus Joint Unit

Roberto Piñeiro completed his doctoral studies on the biology and metabolism of cardiomyocytes in 2005, in the Department of Medicine at the University of Santiago de Compostela. In 2007 he joined the Phosphoinositide group for his post-doctoral in the Blizard Institute, Queen Mary University of London, where he studied the role of the GPR55 receptor and its ligand, lysophosphatidyl inositol (LPI) on cell proliferation in prostate and ovarian cancer.

Then in 2011 he was incorporated into the Cell Signalling group of Barts Cancer Institute, Queen Mary University of London, currently located at the UCL Cancer Institute, University College London. In this laboratory, Roberto worked studying the role of Class I PI3K in cell signalling in cancer and the tumour micro environment using “knock-in” mice and cellular models.

He is currently Head of the Cancer Modelling Line of the Roche-Chus Joint Unit

Experience: animal models, cell cultures, molecular and cell biology, biochemical models.

Interests: ancer cell biology, tumour micro environment, metastasis, oncology, molecular biology.

CONTACT

E-mail: roberto.pineiro.cid@sergas.es
Phone: +34 981 95 56 11

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Original Research Articles

  • Chikh A, Ferro R, Abbott JJ, Piñeiro R, Buus R, Iezzi M, Ricci F, Bergamaschi D, Ostano P, Chiorino G, Lattanzio R, Broggini M, Piantelli M, Maffucci T, Falasca M. Class II phosphoinositide 3-kinase C2β promotes breast cancer progression through modulation of microRNA-449 and cyclin B1. Oncotarget. 2016 Apr 5;7(14):18325-45

  • Ali K, Soond DR, Piñeiro R, Hagemann T, Pearce W, Lim EL, Bouabe H, Scudamore CL, Hancox T, Maecker H, Friedman L, Turner M, Okkenhaug K, Vanhaesebroeck B. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014 Jun 11.

  • Tibolla G, Piñeiro R, Chiozzotto D, Mavrommati I, Wheeler AP, Norata GD, Catapano AL, Maffucci T, Falasca M. Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. PLoS One. 2013;8(1):e53808.

  • Piñeiro R, Maffucci T, Falasca M. The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation. Oncogene. 2011 Jan 13;30(2):142-52.

  • Iglesias MJ, Salgado A, Piñeiro R, Rodiño BK, Diéguez C, Gualillo O, González-Juanatey JR. Lago F. Lack of effect of the ghrelin gene-derived peptide obestatin on cardiomyocytes viability and metabolism. Journal of Endocrinological Investigation. 2007 Jun;30(6):470-6.

  • Iglesias MJ, Eiras S, Piñeiro R, López-Otero D, Fernández A, Gallego R, Lago F, González-Juanatey JR. Influencia del sexo en la expresión de adiponectina y leptina en tejido adiposo epicárdico y subcutáneo. Estudio en pacientes sometidos a cirugía cardíaca. Revista Española de Cardiología. 2006 Dec;59(12):1252-12606.

  • Eiras S, Fernández P, Piñeiro R, Iglesias MJ, González-Juanatey JR, Lago F. Doxazosin induces activation of GADD153 and cleavage of focal adhesion kinase in cardiomyocytes en route to apoptosis. Cardiovascular Research. 71(1):118-28. 2006.

  • Piñeiro R, Iglesias MJ, Eiras S, Viñuela J, Lago F, González-Juanatey JR. Leptin does not induce hypertrophy, cell cycle alterations, or production of MCP-1 in cultured rat and mouse cardiomyocytes. Endocrine Research. 2005; 31:375-86.

  • Piñeiro R, Iglesias MJ, Gallego R, Raghay K, Eiras S, Rubio J, Dieguez C, Gualillo O, González-Juanatey JR, Lago F. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Letters. 2005; 579: 5163-9.

  • Iglesias MJ, Piñeiro R, Blanco M, Gallego R, Diéguez C, Gualillo O, González-Juanatey JR, Lago F. Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes. Cardiovascular Research. 2004; 62: 481-8.

  • González-Juanatey JR, Piñeiro R, Iglesias MJ, Gualillo O, Kelly PA, Dieguez C, Lago F. GH prevents apoptosis in cardiomyocytes cultured in vitro through a calcineurin-dependent mechanism. Journal of Endocrinology. 2004; 180:325-35.

  • González-Juanatey JR, Alcaide C, Iglesias MJ, Piñeiro R, Lago F. Doxazosin induces apoptosis in cardiomyocytes cultured in vitro by a mechanism that is independent of a1-adrenergic blockade. Circulation. 2003; 107:127-131.

Reviews

  • Vanhaesebroeck B, Whitehead M, Piñeiro R. Molecules in medicine mini-review: isoforms of PI3K in biology and disease. J Mol Med. 2016 Jan;94(1):5-11.

  • Piñeiro R, Falasca M. Lysophosphatidylinositol signalling: New wine from an old bottle. Biochim Biophys Acta. 2012 Apr;1821(4):694-705.